Analytical Methods & Lab
Analytical chemistry for chemical engineers, set in a fuel ethanol plant's quality control lab: lab safety, sampling and sample preparation, statistics, calibration and quality control, acid-base, redox, complexometric and Karl Fischer titrations, gravimetry and moisture, UV-visible, infrared, near-infrared and atomic spectroscopy, gas, liquid and ion chromatography, mass spectrometry, and data integrity, uncertainty and ISO/IEC 17025 reporting.
CHE-260 Year 2 3 credits 12 lessons · 4 h 38 min ▶ Video lessons coming soon
Offered by HSM University · Chemical Engineering
This is the Canadian version of this course. See the American version.
What you'll learn
- Work safely in an analytical laboratory: read labels and safety data sheets, use fume hoods correctly, control flammable and compressed gas hazards, and segregate chemical waste.
- Design sampling plans that give representative samples, separate sampling and analysis error, and prepare samples without loss or contamination.
- Describe replicate results with means, standard deviations and confidence intervals, build least-squares calibrations, estimate detection limits and run quality control with control charts.
- Carry out and calculate acid-base, redox, complexometric, precipitation and Karl Fischer titrations, including standardization and end-point location.
- Perform precipitation and volatilization gravimetry, apply gravimetric factors, and convert between as-is and dry-basis results.
- Apply the Beer-Lambert law, operate a UV-visible spectrophotometer, choose measurement conditions and recognize chemical and instrumental deviations.
- Interpret infrared spectra using group frequencies, explain FTIR and ATR, and describe near-infrared and Raman applications with multivariate calibration.
- Compare flame AAS, graphite furnace AAS, ICP-OES and ICP-MS, control their interferences, and calibrate by standard additions and internal standards.
- Explain gas chromatographic separation, calculate plate numbers and resolution, choose columns and detectors, and quantify with internal standards.
- Apply HPLC, ion-exclusion and ion chromatography to sugars, acids and anions, and use the van Deemter equation to explain column efficiency.
- Interpret mass spectra from molecular ions, fragments and isotope patterns, calculate exact-mass errors and describe GC-MS and LC-MS/MS.
- Keep records that meet data integrity principles, build uncertainty budgets, write certificates and technical reports, and explain the requirements of ISO/IEC 17025.
Course content
12 lessons · 4 h 38 min total · final exam
- 1 The analytical laboratory and lab safety 23 min · quiz
- 2 Sampling and sample preparation 22 min · quiz
- 3 Measurement statistics, calibration and quality control 24 min · quiz
- 4 Titration: acid-base, redox, complexometric and Karl Fischer 26 min · quiz
- 5 Gravimetric analysis and moisture 23 min · quiz
- 6 UV-visible spectroscopy and the Beer-Lambert law 24 min · quiz
- 7 Infrared, near-infrared and Raman spectroscopy 24 min · quiz
- 8 Atomic spectroscopy: AAS, ICP-OES and ICP-MS 22 min · quiz
- 9 Gas chromatography 22 min · quiz
- 10 Liquid chromatography and ion chromatography 24 min · quiz
- 11 Mass spectrometry and hyphenated methods 22 min · quiz
- 12 Lab reports, data integrity and ISO/IEC 17025 22 min · quiz
- E Final exam 20 questions
Requirements
Recommended background. You can start any course at any time.
Description
Analytical chemistry for chemical engineers, set in a fuel ethanol plant's quality control lab: lab safety, sampling and sample preparation, statistics, calibration and quality control, acid-base, redox, complexometric and Karl Fischer titrations, gravimetry and moisture, UV-visible, infrared, near-infrared and atomic spectroscopy, gas, liquid and ion chromatography, mass spectrometry, and data integrity, uncertainty and ISO/IEC 17025 reporting.
Part of the Engineering stream, typically taken in year 2.